Collaboration in Natural Product Total Synthesis: Carolacton – A Decade of Discovery

Amy E. Solinski; William M. Wuest

doi:10.1055/s-0040-1707244

Synlett, Table of Contents

Synlett 2021; 32(03): 241-248
DOI: 10.1055/s-0040-1707244

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Collaboration in Natural Product Total Synthesis: Carolacton – A Decade of Discovery

Amy E. Solinski

^aDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA

,

William M. Wuest ∗

^aDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA

^bEmory Antibiotic Resistance Center, Emory University School of Medicine, 201 Dowman Drive, Atlanta, GA 30322, USA Email: wwuest@emory.edu

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Abstract

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Dedicated to Andy Phillips for his mentorship and support.

Abstract

Carolacton, a macrocyclic natural product with impressive anti-biofilm biological activity, has been a focus in multiple research groups for the past decade. Chemists and biologists, alike, have been interested in uncovering the mechanism of action and have made great strides towards this goal. Carolacton causes cellular defects in Streptococcus mutans biofilm, which leads to decreases in cellular viability. As biological targets have been uncovered, synthetic chemists have devised synthetic routes that have helped uncover the important chemical functionalities that lead to biological activity. Herein, we discuss our synthetic collaboration that galvanized an entire research program around the natural product carolacton.

Key words

carolacton - biofilms - natural products - diverted total synthesis - antibiotics

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References

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